- Jenna Axelrod - Stand-up Comic, Actor, Writer and frequent Joke Hunt guest. Has been a guest multiple times on the show. Callers have pointed out that "she sounds like marge simpson". She can be heard in episodes 162 - 2/16/10, 147 - 10/27/09, 141 - 9/15/09, 140 - 9/8/09, 127 - 6/9/09, 130 - 6/30/09, 128 - 6/16/09, 123 - 5/12/09, 114 - 3/3/09.
- Garfunkel & Oats - Riki "Garfunkel" Lindhome and Kate "Oates" Micucci perform songs during the Hot Dog with Veins Episode on 10/13/09.
- Pat cooper - Stand-up Comic and Actor. Made a guest appearance episode in "The Iconic Comic hunt" Episode 149 - 11/10/09.
- Billy West - Voice-Over Actor and former Jackie Puppeteer. Made a guest appearance in "The Relic Hunt" Episode 127 - 6/9/09.
- Red Peters - Musician and songwriter. Host of The Red Peters Comedy Music Hour, appeared on "The Gastric Hunt" Episode 48 on 9/11/07.
